neffy® Study
Please note: The neffy® study is for patients 4 years or older scheduled for an oral food challenge.
Help Shape the Future of Allergic Reaction Treatments
Are you or your child scheduled for an oral food challenge at Children’s National Hospital main campus? You may be able to participate in a research study using neffy® an epinephrine nasal spray approved by the FDA to treat allergic reactions.
About the Study
Epinephrine is used to treat life-threatening, allergic emergencies (e.g., insect stings or bites, foods, drugs and other allergens). neffy® is a novel epinephrine nasal spray that has been approved by the United States (U.S.) Food and Drug Administration (FDA) for the emergency treatment of Type I allergic reactions, including anaphylaxis.
A needle-free epinephrine delivery option may offer clinical benefits by:
- Reducing treatment apprehension and delays
- Reducing accidental injections
- Making the product easier to carry
An FDA-approved intramuscular (IM) epinephrine injection with a needle and syringe called Adrenalin, is commonly used for allergy challenges and is administered by injection deep into the muscle on the upper outer thigh.
What happens during the study?
During the study, you will go through the regular standard-of-care allergy challenge. If treatment is needed, you will be randomized to receive either neffy® or IM epinephrine.
Why is this study being done?
This study is being conducted to evaluate how neffy® compares to manual IM Adrenalin injection with needle and syringe in a real-life clinical setting.
Who can participate?
Individuals who:
- Are scheduled for oral food challenge
- May require treatment
- Would like to have the opportunity to experience neffy® in a controlled setting and under physician supervision
You can help contribute to real-world data on this novel product.
Connect With Us
Interested or want more information? Please email the Allergy Research Office if you would like to learn more about this study and to see whether you or your child may be able to participate. Provide your child’s name, date of birth, your phone number and the study name (“NEFFY”). Or, complete the intake form.