Condition
Constitutional Mismatch Repair Deficiency (CMMRD) Syndrome
Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare genetic condition that greatly increases the risk of developing cancer. It occurs when a child inherits the same change (mutation) in a DNA repair gene from both parents, preventing the body from properly fixing DNA mistakes that happen as cells grow and divide.
What are common symptoms of constitutional mismatch repair deficiency (CMMRD) syndrome?
- Tumors in the brain, spine, digestive tract, urinary or reproductive organs, skin or other parts of the body
- Multiple cancers occurring at a young age
- Light brown skin spots (café au lait spots)
- Areas of skin that are lighter than the surrounding skin (hypopigmented spots)
Schedule an Appointment
Every child with constitutional mismatch repair deficiency (CMMRD) syndrome is different. We are prepared to meet you where you are, provide information and support, as well as the most advanced diagnosis and treatment for any symptoms affecting your child. Meet the doctors and surgeons who treat children with CMMRD and schedule an appointment today.
Frequently Asked Questions
What causes CMMRD?
What is Lynch syndrome?
What cancers are most common with CMMRD?
Is CMMRD known by another name?
Departments that Treat Constitutional Mismatch Repair Deficiency Syndrome
Oncology
The Oncology Program at Children's National is ranked one of the best cancer centers for children by U.S. News & World Report thanks to our high level of experience and expertise. Learn more about this program.
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