What Families Should Know: Leucovorin, Autism and FRAT Testing

Folinic acid, also called leucovorin, is a type of vitamin. Healthcare providers give it to patients who take certain cancer medicines or who have very low folate levels. Folate is a type of vitamin B.

No, leucovorin is not recommended as a regular treatment for autism. It is being studied to treat a rare condition called cerebral folate deficiency (CFD).

Recent public statements have brought attention to leucovorin, but no medical groups currently recommend it for treating autism. The FDA is looking to approve leucovorin for a rare condition called cerebral folate deficiency (CFD). CFD can have some symptoms like autism, but also other problems like seizures and movement issues. We do not prescribe leucovorin for autism unless your child also has CFD.

FRAT is a type of blood test. Research shows that it does not help to diagnose or treat autism. Medical groups do not recommend FRAT testing for children with autism. Many of these tests are not proven and are not paid for by insurance. Children’s National laboratory does not offer this test because we want to protect families from extra costs and procedures.

Most children in studies had mild side effects like upset stomach, trouble sleeping or feeling irritable. However, some children had more agitation or aggression. More research is needed to understand long-term safety.

Leucovorin is not usually given to children with autism unless they are in a research study or have test results showing CFD. Many children do well with supportive therapy, educational strategies and behavioral interventions. Talk to your provider about the best options for your child.