Center for Cancer & Immunology Research
Pei Laboratory
About the Lab
The Pei Laboratory focuses on basic scientific research relevant to medulloblastoma, one of the most common malignant pediatric brain tumors. The group uses novel mouse models and patient-derived xenografts to investigate tumorigenesis and mechanisms underlying therapeutic resistance and identify novel therapies that can ultimately be translated to clinical care to improve patient outcomes.
Featured Publications
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MYC drives group 3 medulloblastoma through transformation of Sox2+ astrocyte progenitor cell
Tao R, Murad N, Xu Z, Zhang P, Okonechnikov K, Kool M, Rivero-Hinojosa S, Lazarski C, Zheng P, Liu Y, Eberhart CG, Rood BR, Packer R, Pei Y PubMed PMID: 30862721; PubMed Central PMCID: PMC6467710. Cancer Res. 79(8):1967-1980. DOI: 10.1158/0008-5472.CAN-18-1787 April (2019) -
HDAC and PI3K antagonists cooperate to inhibit growth of MYC-driven medulloblastoma
Pei Y, Liu KW, Wang J, Garancher A, Tao R, Esparza LA, Maier DL, Udaka YT, Murad N, Morrissy S, Seker-Cin H, Brabetz S, Qi L, Kogiso M, Schubert S, Olson JM, Cho YJ, Li XN, Crawford JR, Levy ML, Kool M, Pfister SM, Taylor MD, Wechsler-Reya RJ PubMed PMID: 26977882; PubMed Central PMCID: PMC4794752 Cancer Cell 29(3):311-323. DOI: 10.1016/j.ccell.2016.02.011 March (2016) -
WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum
Pei Y, Brun SN, Markant SL, Lento W, Gibson P, Taketo MM, Giovannini M, Gilbertson RJ, Wechsler-Reya RJ PubMed PMID: 22461560; PubMed Central PMCID: PMC3328175 Development 139(10):1724-33. DOI: 10.1242/dev.050104 May (2012) -
An animal model of MYC-driven medulloblastoma
Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, Northcott PA, Taylor MD, Pfister SM, Febbo PG, Wechsler-Reya RJ PubMed PMID: 22340590; PubMed Central PMCID: PMC3285431 Cancer Cell 21(2):155-67. DOI: 10.1016/j.ccr.2011.12.021 February (2012) -
A malignant oligarchy: Progenitors govern the behavior of oligodendrogliomas
Pei Y, Wechsler-Reya RJ PubMed PMID: 21156279; PubMed Central PMCID: PMC3012268 Cancer Cell 18(6):546-7. DOI: 10.1016/j.ccr.2010.11.031 December (2010)
