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Center for Translational Research

Guay-Woodford Laboratory

Illustration of two children holding hands

About the Lab

Autosomal recessive polycystic kidney disease (ARPKD; MIM 173900) and other recessive hepatorenal fibrocystic diseases (HRFD) constitute a relatively rare, but important subset of childhood nephropathies that cause significant childhood morbidity and, in some cases, mortality. However, current understanding about the clinical course, molecular pathogenesis, and disease prognosis in affected children is generally limited. Similarly, little is known about childhood autosomal dominant polycystic kidney disease (ADPKD), with the available data largely inferred from adult studies. 

Our research group, the Childhood PKD Research Program, focuses on laboratory-based investigations and clinical research to advance the understanding of childhood polycystic kidney disease (PKD).