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Leigh Jessica Marcus, MD

The Center for Cancer and Blood Disorders


Leukemia/ Lymphoma Program

Board CertificationsAmerican Board of Pediatrics
National Provider Identifier1295933992

Service LocationsChildren's National Medical Center - Sheikh Zayed Campus for Advanced Children's Medicine
111 Michigan Avenue, NW
Washington, DC 20010
Map | Driving Directions

Phone: 202-476-5000

Leigh Marcus, MD, is an Assistant Professor at The George Washington School of Medicine and Attending Physician at the Center for Cancer and Blood Disorders. She is a member of the Leukemia & Lymphoma Program in the Division of Oncology at Children’s National Medical Center, and specializes in Non-Hodgkin’s Lymphoma. Dr Marcus serves as a member of the Children’s Oncology Group (COG) Non-Hodgkin’s Lymphoma subcommittee, which is the international consortium for children with cancer. She is also their Young Investigator (YI) liaison. Dr Marcus is Principle Investigator (PI) for Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL), the early phase clinical trials consortia for leukemia and lymphoma in childhood. Dr Marcus is the Responsible Investigator (RI) on most acute lymphoblastic leukemia COG trials at Children's National. She also is the assistant medical unit director of the inpatient hematology/oncology/bone marrow unit at Children's. Dr Marcus has been an invited speaker at various venues including Food and Drug Administration (FDA), American Association for Clinical Research (AACR), Johns Hopkins Hospital, and National Cancer Institute (NCI) at National Institutes of Health (NIH).
TypeSchoolLocationDegreeField of StudyYears
Undergraduate Education University of North Carolina at Chapel Hill Chapel Hill, NCBachelor of Science 1996 -2000
Medical School Medical College of Virginia Richmond, VADoctor of Medicine 2000 -2004
Affiliations and Memberships
TitleInstitutionCommittee / SectionYears
MemberAmerican Academy of Pediatrics2007
MemberChildren’s Oncology Group
Member, Principle InvestigatorTherapeutic Advances in Childhood Leukemia and Lymphoma
TitleStudy NameInstitutionYears
InvestigatorPhase I/II Trial of Vandetanib in Children and Adolescents with Hereditary Medullary Thyroid Carcinoma2010
InvestigatorPhase I trial of the mitogen activated protein kinase (MEK) 1 inhibitor AZD6244 in children with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PN)
InvestigatorPhase I trial and pharmacokinetic study of satraplatin in children and adolescents with refractory solid tumors including CNS tumors2010
InvestigatorPhase 2 Study of Bevacizumab in Children and Adults with Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma
InvestigatorA Phase I Trial and Pharmacokinetic Study of Trabectedin (YONDELIS®, ET-743) in Children and Adolescents with Relapsed or Refractory Solid Tumors
Journal Article, Lodish M, Dagalakis U, Chen CC, Sinaii N, Whitcomb P, Aikin A, Dombi E, Marcus L, et al. (2012), In-Octreotide Scintigraphy for Identification of metastatic medullary thyroid carcinoma in Children and Adolescents, The Journal of Clinical Endocrinology & Metabolism, 97, 2, 207-212.

Journal Article, Marcus L, Murphy R, Fox E, McCully C, Cruz R, Warren KE, Meyer T, McNiff E, Balis FM, Widemann BC (2012), The plasma and cerebrospinal fluid pharmacokinetics of the platinum analog satraplatin after intravenous administration in non-human primates, Cancer Chemotherapy and Pharmacology, 69, 1, 247-252.

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