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Joshua Corbin, PhD
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Children's National Medical Center
Principle Investigator
Children's Research Institute (CRI),
Center for Neuroscience Research (CNR)
George Washington University
School of Medicine and Health Sciences
Assistant Professor, Pediatrics, Pharmacology and Physiology |
Contact Information
Children's National Medical Center
Center for Neuroscience Research (CNR)
111 Michigan Avenue, NW
Washington, DC 20010-2970
202-476-6281
jcorbin@cnmcresearch.org
Education & Training
| Institution & Location |
Degree |
Year(s) |
Field of Study |
| Rutgers College, New Brunswick, NJ |
BA |
1985-1989 |
Biology |
University of North Carolina,
Chapel Hill, NC |
PhD |
1991-1996 |
Neuroscience |
| Mt. Sinai School of Medicine |
Post Doc |
1996-1998 |
Neuroscience |
Skiball Institute-
NYU School of Medicine |
Post Doc |
1998-2004 |
Developmental
Neuroscience |
Research Interests
Joshua Corbin, PhD, studies the genetic and cellular basis of the development of the mammalian amygdala. The amygdala is a major component of the brain's limbic system, a functionally interconnected set of forebrain structures that also includes the hippocampus, prefrontal and cingulate cortices, hypothalamus, and nucleus accumbens. Despite an extensive understanding of amygdala function and anatomy, currently little is known regarding the embryonic development of this complex structure. Using the mouse as an experimental model, the Corbin lab examines how migrating neural progenitor cells in the developing telencephalon contribute to neuronal cell diversity in the mature amygdala and how these cells become wired together to form mature brain circuits. The ultimate goal of these studies is to understand the link between developmental events and the assembly of the mature amygdala at a genetic, cellular, structural, and functional level. To investigate these questions a variety of tools are employed. These include the generation and analysis of conditional knockout mice, cell-specific lineage tracing using recombination-mediated lineage marking in transgenic animals, and ultrasound-guided imaging to deliver labeled cells or retroviruses to the early developing embryonic telencephalon at developmental times that were previously inaccessible. From these studies, the hope is to not only elucidate the normal mechanisms of brain development, but also gain a greater understanding of the etiology of developmental disorders in which development of the amygdala is affected.
Laboratory Members
Laura Cocas
Rosalind Carney, PhD
Tsutomu Hirata, PhD
Luis Olmos, PhD
Grant Support
NIH R01 DA020140, 2006-2011
Children’s RAC Award, 2008
Completed Research Support
National Alliance for Autism Research (NAAR) Pilot Grant 2005-2007
MRDDRC Research grant, 2005-2006
Children’s RAC Award, 2007
Publications
View a partial list of Joshua Corbin's publications through the National Library of Medicine's PubMed online database.
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