| |
|
|
| |
|
|
| |
Terence A. Partridge, PhD
 |
Children's National Medical Center
Principal Investigator, Children's Research Institute
Center for Genetic Medicine Research (CGMR)
George Washington University
School of Medicine and Health Sciences
Professor, Pediatrics |
Contact Information
Children's National Medical Center
Center for Genetic Medicine Research (CGMR)
111 Michigan Avenue, NW
Washington, DC 20010-2970
202-476-6029
tpartridge@cnmcresearch.org
Education & Training
| Institution & Location |
Degree |
Year(s) |
Field of Study |
| University College London, London, UK |
BSc |
1962 |
Zoology |
| University College London, London, UK |
PhD |
1970 |
Zoology (Embryology) |
Research Interests
Terry Partridge, PhD, developed an early fascination with biology, and subsequently went on study Zoology at University College London, gaining a BSc degree and later, at the same institution, a PhD on cell behavior under the supervision of Professor Michael Abercrombie. After an interlude at the Museum Nationale d’Histoire Naturelle in Paris, where he worked on rodent malaria as a model of the human disease, Dr. Partridge was appointed in 1967 as an assistant lecturer in the Department of Cell Biology in the University of Glasgow. In 1970, he took up a research post in Charing Cross Hospital Medical School in the University of London, on the idea that circulating stem cells might participate in regeneration of skeletal muscle and act as vectors for the genetic treatment of muscular dystrophy. This line of work has marked his career ever since, despite his disproof of the original idea. He provided, in collaboration with Eric Hoffman, the first demonstration that grafts of muscle precursor cells could be used to introduce good copies of defective genes into genetically defective dystrophic muscle fibres. The question of what controls muscle size and function and what are the sources of myogenic cells for maintenance of this tissue has remained an obsession. In 1994, he moved to a Medical Research Council research institute at the Hammersmith Hospital in London, as head of the Muscle Cell Biology Unit where his team undertook the construction of experimental systems for approximating the studies of muscle cell biology in vitro to the relevant phenomena that can be observed in vivo. Particular advances were the use of single isolated living muscle fibers and the development of new methods for identifying the muscle satellite cells that appear to be the main source of precursor cells for muscle reeneration. An additional interest in recent years has been the phenomenon of exon-skipping in the dystrophin gene, both the spontaneously occurring phenomenon and the artificial induction of targeted exon-skipping that currently offers among the most promising prospects for treatment of Duchenne muscular dystrophy. Dr. Partridge joined the Center for Genetic Medicine at the Children’s National in December 2005, with the intention of allying with the existing structures and interests within the Center to continue his research both on muscle cell biology and on the use of exon-skipping technology for the treatment of Duchenne Muscular dystrophy.
Publications
View a partial list of publications for Terence A. Partridge, PhD through the National Library of Medicine's PubMed online database.
Back to Top
|
|
|
|
|
|
