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Tumor Host Interactions
In the field of cancer biology, studies of a series of interactions between the tumor cell and host, within the microenvironment of the tumor, constitute a primary area of investigation. Tumor-host interactions are increasingly recognized as critical to survival and progression of tumors. This field of study encompasses tumor cell adhesion and migration, development of neovasculature, and immune responses to the tumor by the host. Of particular interest are studies of how the tumor cell modulates these tumor host interactions. The research of Stephan Ladisch, MD, and Kelly Stone MD, PhD, explores the relationship between molecules shed by tumor cells (gangliosides) and the host anti-tumor immune response as it may exist in the tumor microenvironment. Stanislav Vukmanovic, MD, PhD, and Tobey J. MacDonald, MD, study immune parameters of medulloblastoma to identify potential defects in anti-tumor responses in patients. This will help attempt to boost the defective parts of the immune response therapeutically. Sasa Radoja, PhD, has studied immune response of tumor bearers using various mouse models and is currently planning to study cytotoxic T cell function of tumor infiltrating lymphocytes from cancer patients.
For more information contact:
Stanislav Vukmanovic, MD, PhD
Children's Research Institute
Center for Cancer and Immunology Research
Children's National Medical Center
111 Michigan Avenue, NW
Washington, DC 20010
202-476-3898
202-476-3929 fax
svukmano@cnmc.org
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