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Developmental Neuroscience Research
Developmental neuroscientists study the mechanisms of how the nervous system develops in utero and during early stages after birth. At Children’s National Medical Center, researchers study many different aspects of nervous system development--from early stages, when the nervous system is first established, to post natal stages that include the formation of neuronal connections and the wrapping of neuronal processes by the myelin insulator. Alterations in these processes result in a variety of childhood disorders that include neural tube defects (e.g. spina bifida), Fragile X syndrome, autism, Down syndrome, epilepsy, as well as myelination disturbances resulting from changes in the normal levels of oxygen.
Children’s developmental neuroscience team actively researches
- How cell cycle and lineage progression are regulated during cortical development
- The genetic and cellular basis of the development of the brain's limbic system
- Genetic and cellular events in animal models of neural tube closure defects
- Animal models of autism spectrum disorders and Down Syndrome
- Normal and abnormal myelin and white matter development
- Morphogen signaling in the nervous system
- Neurotransmitter regulation
- Ion channel regulation in glia
Faculty who study developmental neuroscience
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