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Molecular Genetics/Proteomics
The overall objective of the Molecular Genetics/Proteomics Core is to provide all investigators with basic and advanced molecular biology, molecular genetics, and genetic counseling tools to strengthen clinical research. The Core offers a range of mass spectrometry services including:
- Experimental design and implementation (selection of technique)
- Method development (extraction, separation, detection, quantification)
- Method validation and quality control
- Synthesis of stable isotopes
- Sample processing
- Data collection and interpretation
The Core’s services also include
- Automated sequencing
- SNP discovery
- SNP genotyping
- Expression profiling using microarrays
- Assistance with experimental design and implementation
- Processing of Affymetrix GeneChips
- Interpretation of data, and verification/validation
- Data dissemination
- Genetic counseling support
- Study design and implementation
- IRB/GAC and consent form assistance for genetics studies
- Patient confidentiality consultation
- Sample storage and referral
- High-throughput proteomic profiling methodologies
- DNA Sequence And Mutation Analyses
- Molecular diagnosis, mutation detection
- SNP association studies
- Automated sequence analysis
- DHPLC testing for localization of changes and genotyping
- TTGE mutation detection system
- TGCE mutation Reveal system
- mRNA Quantitative Reverse Transcriptase-Polymerase Chain Reaction
(RT-PCR) and PC R
- LiCor IR2 quantification
- TaqMan quantification
- Laser capture microdissection (Arcturus, Leica)
For more information, contact Eric P. Hoffman, PhD
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