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Diabetes
There is increasing public concern about the epidemic of obesity and associated type 2 diabetes. The most recent reports from the CDC have suggested that nearly 30 percent of children born in the year 2000 will develop type 2 diabetes, with an average 18-22 year loss of life (quality adjusted life years). Yetrib Hathout, PhD, and Eric P. Hoffman, PhD, have initiated a series of collaborative studies on metabolic syndrome and type II diabetes. For example, they have recently found that muscle metabolism changes dramatically increase the progression from normal, to obese, to morbid obesity. Additional collaborations are with endocrinologists and nutritionists at Children’s National Medical Center (Lauren Rhee, MS, Nazrat M. Mirza, MD, ScD, Susan B. Nunez, MD). Two NIH-funded projects include a study of SNPs in children with type 2 diabetes and obesity, and an exercise intervention in overweight minority adolescents to study effects on insulin resistance and serum fibrinolysis. Dr. Mirza recently received an outstanding score on a K23 application, and she will work towards further understanding the effect of interventions on high risk obesity pediatric populations.
Related Links
National Institute of Child Health and Human Development
www.nichd.nih.gov
Juvenile Diabetes Research Foundation International
www.jdrf.org/
Medline
www.ncbi.nlm.nih.gov
Contact Information
Eric P. Hoffman, PhD
Children's Research Institute
Research Center for Genetic Medicine
Children's National Medical Center
111 Michigan Avenue, NW
Washington, DC 20010
202-476-6029
202-476-6014 fax
ehoffman@cnmcresearch.org
Catherine J. Klein, PhD, RD, CNSD
Director, Bionutrition Research Program
General Clinical Research Center, 3rd Floor
Children's National Medical Center
111 Michigan Avenue, N.W.
Washington D.C., 20010
Phone Office: 202-476-2910
Phone GCRC: 202-476-2922
Fax: 202-476-6636
Assistant Research Professor
Department of Pediatrics, George Washington University School of Medicine and Health Sciences
CKlein@cnmc.org
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