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Pedro A. Jose

The Center for Heart, Lung and Kidney Disease

Departments
Nephrology


Children’s Research Institute (CRI)
Center for Molecular Physiology Research

National Provider Identifier
E-Mail
Biography

Dr. Jose completed his training in Pediatric Nephrology at Georgetown University Medical Center. Dr. Jose's main focus is on determining the genes that increase the risk of development of high blood pressure and predict the response to anti-hypertensive therapy. Dr. Jose . He is certified by the American Board of Pediatrics, American Sub-Board of Pediatric Nephrology, and American Society of Hypertension. He was President of the American Society of Pediatric Nephrology. Dr. Jose has chaired Study Sections and Emphasis Panels of the National Institutes of Health and voluntary organizations, such as the American Heart Association and National Kidney Foundation. He has published over 290 scientific articles in prestigious journals including Circulation Research, Journal of Clinical Investigation, Hypertension, Nature Genetics, and the Proceedings of the National Academy of Sciences. His publications have been cited more than 6,000 times with 29 cited more than 50 times and 15 cited more than 100 times. Four have been chosen as covers of scientific journals and four have been the subject of editorial commentaries. A key finding of Dr. Jose and coworkers is the demonstration of the crucial role of variants of a gene called “G protein-coupled receptor kinase type 4 or GRK4” in the etiology of high blood pressure in humans. Dr. Jose and coworkers also showed that variations of GRK4 are very important in predisposing an individual to develop high blood pressure, also known as essential hypertension, especially if too much sodium chloride is eaten. The presence of these gene variants, by themselves, or in association with variants of genes known to regulate blood pressure, can be used to predict the hypertensive trait and response to drugs used to treat hypertension.
National & International Recognitions
AwardInstitutionEventYear
NIH MERIT AwardNational Institutes of Health, National Heart, Lung, and Blood Institure2007
Ernest H. Starling LectureAmerican Physiological 20072007
Lewis K. Dahl Memorial Lecturer Council for High Blood Pressure Research, American Heart Association2003
Publications
Journal Article, Pinto V, Pinho MJ, Jose PA, Soares-da-Silva P. (2010), Role of H2O2 on the kinetics of low-affinity high-capacity Na -dependent + alanine transport in SHR proximal tubular epithelial cells., Biochem Biophys Res Commun, 398, 553-558.

Journal Article, Wang D, Luo Z, Wang X, Jose PA, Falck JR, Welch WJ, Aslam S, Teerlink T, Wilcox CS. (2010), Impaired Endothelial Function and Microvascular Asymmetrical Dimethylarginine in Angiotensin II–Infused Rats: Effects of Tempol, Hypertension, 56, 950-955.

Journal Article, Wang X, Li F, Jose PA, Ecelbarger CM. (2010), Reduction of Renal Dopamine Receptor Expression in Obese Zucker Rats: Role of Sex and Angiotensin II., Am J Physiol: Renal Physiol. , 299, 5, 1164-1170.

Journal Article, Yokokawa H, Sanada H, Goto A, Watanabe T, Felder RA, Jose PA, Eisner GM, Yasumura S. (2010), Characteristics of Antihypertensive Medication and Change of Prescription Over 1 Year of Follow Up in Japan: Fukushima Research of Hypertension (FRESH)., Am J Hypertens., 23, 1299-1305.

Journal Article, Simão S, Gomes P, Jose PA, Soares-da-Silva P. (2010), Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl /HCO3 exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR., Biochem Pharmacol, 80, 913-919.

Other (2010), Mol Pharmacol, (Cover), 78, 1.

Book Chapter, Natarajan A, Jose PA. (2008), Renal modulation: the renin-angiotensin-aldosterone system (RAAS)., In Oh W, Guignard JP, Baumgart S (ed), Nephrology and Fluid/Electrolyte Physiology. Neonatology Questions and Controversies., 107-127, Elsevier.

Other, Armando I, Jose PA. (2008), Hypertension, Sensoring salt intake., 53, 118-119.

Book Chapter, Jose PA, Jones JE, Williams SM, Eisner GM, Felder RA. (2007), Genetics and renal pathophysiology of essential hypertension., In Pollack M, Mount DB (eds), The Molecular and Genetic Basis of Renal Disease., 347-372, Elsevier Saunders, PA.

Book Chapter, Felder RA, Carey RM, Jose PA. (2007), The renal dopaminergic system, hypertension, and salt sensitivity., In Felder RA, Carey RM, Jose PA., Hypertension and Hormone Mechanisms, 159-172, Humana Press, Inc., Totowa, NJ.



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