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David Leitenberg, MD

The Center for Cancer and Blood Disorders

Laboratory Medicine

Leukemia/ Lymphoma Program

Children’s Research Institute (CRI)
Center for Cancer and Immunology Research
Specialties: Allergic and Immunologic Disorders, Leukemia, Non-Hodgkin Lymphoma, Primary Immunodeficiency Diseases

Board CertificationsAmerican Board of Pathology
National Provider Identifier1710047394

Service LocationsChildren's National Medical Center - Sheikh Zayed Campus for Advanced Children's Medicine
111 Michigan Avenue, NW
Washington, DC 20010
Map | Driving Directions

Phone: 202-476-5000

David Leitenberg, MD, PhD, is the director of the Immunology Laboratory in the Division of Laboratory Medicine.
TypeSchoolLocationDegreeField of StudyYears
Undergraduate Education University of Vermont Burlington, VTBachelor of Arts 1979 -1983
Medical School University of Iowa College of Medicine Iowa City, IADoctor of Medicine 1990
National & International Recognitions
Arthritis Investigator AwardArthritis Foundation1998
Research Scholar GrantAmerican Cancer Society

Affiliations and Memberships
TitleInstitutionCommittee / SectionYears
MemberAmerican Association of Immunologists
TitleStudy NameInstitutionYears
Principal InvestigatorCD45 Regulation of T lymphocyte activationAmerican Cancer Society2005 - 2009
InvestigatorGangliosides and the Biology of Human NeuroblastomaNational Institutes of Health/National Cancer Institute2004 - 2009
Principal InvestigatorCD45 Regulation of T lymphocyte activationNational Institutes of Health/National Institute of Allergy and Infectious Diseases1999 - 2005
Journal Article, Falahati, R., Leitenberg, D. (2008), Selective regulation of TCR signaling pathways in primary thymocytes by the CD45 tyrosine phosphatase, Journal of Immunology, 181, 6082-6091.

Journal Article, Shen, W., K. Stone, A. Jales, D. Leitenberg, S. Ladisch (2008), Inhibition of TLR Activation and Up-Regulation of IL-1R-Associated Kinase-M Expression by Exogenous Gangliosides, Journal of Immunology, 180, 4425-4432.

Journal Article, Leitenberg, D., Falahati, R., Lu, D., and Takeda (2007), CD45-associated protein regulates the response to low-potency T cell stimulation and promotes CD45 association with CD3/TCR and lck, Immunology, 121, 545-554.

Journal Article, Falahati, R., and D. Leitenberg (2007), Changes in the role of the CD45 Protein Tyrosine Phosphatase in Regulating of Lck Tyrosine Phosphorylation During Thymic Development, Journal of Immunology, 178, 2056-2064.

Journal Article, Gwinn, W., J. Damsker, R. Falahati, I. Okwumabua, A. Kelly-Welsh, A. Keegan, C. Vanpouille, J. Lee, L. Dent, D. Leitenberg, M. Bukrinsky and S. Constant (2006), Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention, Journal of Immunology, 177, 4870-4879.

Journal Article, Shen, W., R. Falahati, R. Stark, D. Leitenberg, and S. Ladisch (2005), The modulation of CD4 T helper cell differentiation by ganglioside GD1a in vitro, Journal of Immunology, 175, 4927-4934.

Journal Article, Meloni-Ehrig, A.M., Tirado, C.A., Chen, K., Jahn, J., Suchan, S., Scheerle, J., Crosby, M.G., Meany, H., Seibel, N., Leitenberg, D., Heritage, D.W., Mowrey, P.N. (2005), Isolated del (14)(q21) in a case of preursor B-cell acute lymphoblastic leukemia, Cancer Genetics and Cytogenetics, 161, 1, 82-85.

Journal Article, Tatari-Calderone, Z., Brogdon, J.L., Tinsley, K., Ramezani, A., Leitenberg, D. (2005), CD4-dependent regulation of activation-induced cell death promotes selection of Th2 effector cells, Journal of Immunology, 175, 5629-5636.

For a more comprehensive list of publications for David Leitenberg, MD view the National Library of Medicine’s PubMed online database

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